Using one-molecule optical and AFM imaging and power-spectroscopy methods, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits include things like:

It had been only during the nineteen nineties though, when nanotechnology had Sophisticated to some degree the place solitary molecules may very well be manipulated, that the 1st experimental equipment commenced to look.

, Groningen researchers existing the outcome in their efforts to generate labs a lot more sustainable and provide guidelines for other labs. 

Our do the job was immediately adopted up by others, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 published their findings on transistors made from single- and multi-walled carbon nanotubes in Applied Physics Letters.

2010, produced a whole new way (‘wedging transfer’) to govern nanostructures; first report of DNA translocation by way of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into stable-point out nanopores

Immediate immobilization of indigenous yeast iso-1 cytochrome c on bare gold: rapidly electron relay to redox enzymes and zeptomole protein-film voltammetry

MATLAB codes for data processing are offered at . Julia codes useful for numerical simulation can be obtained at .

Atomic pressure microscopy reveals that vaccinia topoisomerase IB generates filaments on DNA inside a cooperative trend

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Resolving the phase measurement in condensin-driven DNA loop extrusion identifies ATP binding because the stage-generating procedure

An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes

‘That problems the synthetic cell, as part of the Dutch BaSyC initiative. Craig Venter seemed major-down in Individuals times and discovered about five hundred genes that happen to be minimally needed for the performing cell. We want to glance base-up: how do we transfer from the couple molecules to a complete biological system?

2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of long-selection conformational variations in Mre11/DNA fix complexes; and to start with force measurements on the DNA molecule in a very nanopore

‘I am driven by surprise and inquiries. On a cloth amount I find answers in physics, but I practical experience my deepest contentment with God. That religion also drives my science and how I cope with folks.